Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Adhansia XR: 25 mg PO qAM initially; may titrate upward in increments of 10-15 mg at intervals of at least 5 days; dosages >85 mg/day associated with increased incidence of certain adverse reactions, Aptensio XR: 10 mg PO qDay in AM; may increase weekly by 10-mg increments; not to exceed 60 mg/day, Concerta: Initial for methylphenidate-nave, 18-36 mg PO qDay; may increase by 18-mg increments at weekly intervals; maintenance dose is 18-72 mg/day, Metadate CD: Initial, 20 mg PO qAM before breakfast; may increase in 10- to 20-mg increments; not to exceed 60 mg/day, Methylin ER: Duration of action ~8 hr; may use in place of methylphenidate IR tablets when 8-hr dosage of methylphenidate ER corresponds to titrated 8-hr dosage of methylphenidate IR; not to exceed 60 mg/day, Ritalin (immediate-release tablets and oral solution): 20-30 mg/day PO divided q8-12hr, 30-45 minutes before meals; may gradually increase dose at weekly intervals; some patients may require 40-60 mg/day; in others, 10-15 mg/day may be adequate, QuilliChew ER (chewable extended-release tablets): 20 mg PO qAM initially; may titrate up or down weekly in increments of 10 mg, 15 mg, or 20 mg; not to exceed 60 mg/day, Jornay PM: Initial, 20 mg PO qDay in the evening; may titrate weekly in increments of 20 mg; not to exceed 100 mg/day; initiate dosing at 8:00 pm; adjust timing of administration between 6:30 pm and 9:30 pm to optimize tolerability and efficacy the next morning and throughout the day, Relexxii: Initial for methylphenidate-nave, 18-36 mg PO qDay; may increase by 18-mg increments at weekly intervals; maintenance dose is 18-72 mg/day; not to exceed 72 mg/day, Ritalin LA: Initial, 20 mg PO qAM; may adjust dose in weekly 10-mg increments, not to exceed 60 mg/day (patients requiring a lower initial dose may begin with 10 mg), Methylin, Ritalin (immediate-release tablets and oral solution): 20-30 mg/day PO divided q8-12hr, 30-45 minutes before meals; some patients may require 40-60 mg/day; in others, 10-15 mg/day may be adequate, Methylin ER: Duration of action is approximately 8 hr; may use in place of methylphenidate IR tablets when 8-hr dosage of methylphenidate ER corresponds to the titrated 8-hr dosage of methylphenidate IR, <6 years: Safety and efficacy not established. Monitor Closely (1)esomeprazole decreases effects of methylphenidate by enhancing GI absorption. Methylphenidate may diminish antihypertensive effects. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Other (see comment). Monitor for decreased therapeutic effects of methylphenidate if carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased. magnesium oxide decreases effects of methylphenidate by enhancing GI absorption. Risk of acute hypertensive episode. amitriptyline, methylphenidate. Additive vasospasm; risk of hypertension. Monitor Closely (1)methylphenidate will decrease the level or effect of phentolamine by pharmacodynamic antagonism. Conversion dosage should not exceed 72 mg daily. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Contraindicated (1)diethylpropion increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)pimavanserin increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)rotigotine, methylphenidate. caffeine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Monitor BP. Potential for additive CNS stimulation. Monitor Closely (1)amitriptyline, methylphenidate. Use Caution/Monitor. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Risk of acute hypertensive episode. Contraindicated. Monitor Closely (1)methylphenidate increases toxicity of trazodone by Other (see comment). Applies only to extended release formulationnizatidine decreases effects of methylphenidate by enhancing GI absorption. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Methylphenidate may diminish antihypertensive effects. cabergoline, methylphenidate. Methylphenidate may diminish antihypertensive effects. Interaction more likely in certain predisposed pts. only. maprotiline, methylphenidate. Methylphenidate may diminish antihypertensive effects. Other (see comment). Methylphenidate may diminish antihypertensive effects. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Tranylcypromine. Use Caution/Monitor. Use Caution/Monitor. serdexmethylphenidate/dexmethylphenidate and methylphenidate both decrease sedation. Monitor Closely (1)nortriptyline, methylphenidate. Risk of acute hypertensive episode. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)aspirin/citric acid/sodium bicarbonate decreases effects of methylphenidate by enhancing GI absorption. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Comment: Green tea may include caffeine. Applies only to oral form of both agents. Use Caution/Monitor. Monitor BP. methylphenidate will decrease the level or effect of isradipine by pharmacodynamic antagonism. However, the dose is usually not more than 60 mg per day. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Additive vasospasm; risk of hypertension. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Potential for additive CNS stimulation. phendimetrazine increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. Other (see comment). trimipramine, methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Comment: Green tea may include caffeine. Risk of V tach, HTN. Comment: Potential for additive CNS effects. Monitor Closely (1)methylphenidate will decrease the level or effect of moexipril by pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of losartan by pharmacodynamic antagonism. Adderall) in the left column Enter your patient's current dosage Choose your patient's new medication (e.g. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. ether increases toxicity of methylphenidate by Mechanism: unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Contraindicated. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. guarana increases effects of methylphenidate by pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Contraindicated. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Applies only to oral form of both agents. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Please confirm that you would like to log out of Medscape. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Selegiline. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)fenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Ritalin (methylphenidate) 5-, 10-, and 20-mg tablets: 5 mg BID before breakfast and lunch; . commonly, these are "non-preferred" brand drugs. hydrocodone, methylphenidate. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Contraindicated. Other (see comment). Currently on methylphenidate 5 mg BID or . Monitor Closely (1)methylphenidate will decrease the level or effect of nifedipine by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Monitor Closely (1)methylphenidate will decrease the level or effect of olmesartan by pharmacodynamic antagonism. Use Caution/Monitor. restrictions. Contraindicated (1)selegiline transdermal increases effects of methylphenidate by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)loxapine inhaled increases toxicity of methylphenidate by pharmacodynamic antagonism. Avoid or Use Alternate Drug. This website also contains material copyrighted by 3rd parties. atomoxetine (strattera ) Drug Category: Selective Norepinephrine Reuptake Inhibitor. Avoid or Use Alternate Drug. Ritalin (immediate-release tablets and oral solution): 20-30 mg/day PO divided q8-12hr, 30-45 minutes before meals; may gradually increase dose at weekly intervals; some patients may require 40-60 mg/day; in others, 10-15 mg/day may be adequate . Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Contraindicated. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Applies only to oral form of both agents. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Applies only to extended release formulation famotidine decreases effects of methylphenidate by enhancing GI absorption. Risk of acute hypertensive episode. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. Monitor BP. amoxapine, methylphenidate. Monitor Closely (1)benzhydrocodone/acetaminophen, methylphenidate. Additive vasospasm; risk of hypertension. Use Caution/Monitor. Monitor Closely (2)fluphenazine, methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of prazosin by pharmacodynamic antagonism. Risk of acute hypertensive episode. Potential for additive CNS stimulation. The generic drug name of Concerta is methylphenidate. Monitor BP. Minor/Significance Unknown. doxapram increases effects of methylphenidate by pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Avoid or Use Alternate Drug. Use Caution/Monitor. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Risk of acute hypertensive episode. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. dihydroergotamine intranasal, methylphenidate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Interaction more likely in certain predisposed pts. methylergonovine, methylphenidate. Modify Therapy/Monitor Closely. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)apomorphine, methylphenidate. For example, Ritalin 10 mg q4h is converted to Concerta 36 mg. For many patients, effects of the OROS tablets last only 9-10 hours and patients also commonly describe the medication as taking longer than others to take effect. Use Caution/Monitor. Serious - Use Alternative (1)maprotiline, methylphenidate. chlorpromazine, methylphenidate. The recipient will receive more details and instructions to access this offer. Monitor BP. Either increases effects of the other by pharmacodynamic synergism. only.perphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. methylphenidate will decrease the level or effect of sotalol by pharmacodynamic antagonism. aspirin/citric acid/sodium bicarbonate decreases effects of methylphenidate by enhancing GI absorption. Avoid or Use Alternate Drug. Monitor BP. Use Caution/Monitor. Indication: attention-deficit/hyperactivity disorder (ADHD). Use Caution/Monitor. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Are Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Significantly Linked to Childhood Allergies? Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)thioridazine, methylphenidate. Interaction specifically associated with Ritalin LA. Risk of acute hypertensive episode. trifluoperazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. The recommended dose of CONCERTA for patients who are currently taking methylphenidate twice daily or three times daily at doses of 10 to 60 mg/day is provided in Table 2. Instructions to access this offer methylphenidate by pharmacodynamic antagonism ) fenfluramine and methylphenidate both increase (. Following discontinuation of an MAOI more than 60 mg per day ) diethylpropion increases effects of by! 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Blood pressure and heart rate, carefully observe the patient, particularly during treatment with an and!, there is a potential for serious adverse reactions, including hypertensive crisis of trazodone by (... If carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased pressure and rate. Transdermal increases effects of methylphenidate by pharmacodynamic antagonism of an MAOI and also within a minimum of 14 days discontinuation. An MAOI and also within a minimum of 14 days following discontinuation of an MAOI and also within minimum... Gi absorption - use Alternative ( 1 ) aspirin/citric acid/sodium bicarbonate decreases of... And 20-mg tablets: 5 mg BID before breakfast and lunch ; decrease the level or of... Material on this website is protected by copyright, copyright 1994-2023 by WebMD LLC would like to log of. Treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI and also a...
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