Higgins RM, Daga S, Mitchell DA. Insights to the epidemiology, pathogenesis and immune processes underlying renal health challenges has led to the introduction of new therapies and treatments. We particularly welcome studies that are directly relevant to patient care, inclusive of clinical trial outcomes, and studies that focus on translating new therapies to the clinic. (24), whose risk factors included female recipients. Asia. |, Creative Commons Attribution License (CC BY). Montgomery RA, Lonze BE, King KE, Kraus ES, Kucirka LM, Locke JE, et al. (C) Comparison of CysC normal percentage between groups of different ranges of recipients' BMI at different time points follow up after surgery. Frontiers in Pharmacology is the world’s 2nd most-cited open-access journal in its field and ranks in the top Impact Factor and CiteScore percentiles. Kidney Int. In the future, we will collect the basic information of donors as completely as possible to investigate the influence of donor factors on transplantation kidney function. From the multivariate logistic regression analysis, recipient gender, ethnicity, BMI, and donor age were independent factors affecting postoperative CysC recovery at discrete time points. (2014) 27:19–27. (2017) 17:250. doi: 10.1186/s12913-017-2190-7, 19. Future research will ideally collect data 10 years or more after surgery. First, though the quantity of samples is large, this study is only a single-center retrospective analysis, certain restrictions not only in the region but also in the time period still exist. We aim at building a valuable resource for clinicians and researchers to exchange innovative ideas and practices and to access cutting-edge research on basic, clinical and translational nephrology. We subsequently excluded subjects with unknown transplant date (N = 3) and those without clinical data on CysC examination and recipient or donor baseline characteristics (N = 602). The aim is to act as a platform for translational research between scientists and clinicians. Consistent with our results, several studies in the literature have shown a strong association between age and adverse effect in kidney transplantation (31, 32). (2019) 20:409. doi: 10.1186/s12882-019-1557-x, 23. This retrospective study was approved by the Biomedical Ethics Subcommittee of West China Hospital of Sichuan University [reference No. Antus B, Yao Y, Song E, Liu S, Lutz J, Heemann U. All of these changes and new developments need to be properly and timely examined, summarized and presented to all stakeholders. peter.heeger@mssm.edu support@frontiersin.org. doi: 10.1111/ctr.13036, 33. Impact Factor. Gender of recipients and gender-consistency between donors and recipients revealed both short-term and long-term influence. It followed Chinese laws and regulations and met ethical requirements. Donors recorded in the Transplant Center Database include immediate or collateral blood-related relative living donors within three generations (n = 1,960), as well as, unrelated donors (n = 497) who were spouse donors (n = 155), a foster father donor (n = 1), and donors after cardiac death (DCD) (n = 341). Outcomes for primary kidney transplantation from donation after Citizens' death in China: a single center experience of 367 cases. Frontiers in Behavioral Neuroscience. National Clinical Research Center for Oral Diseases (China) About. Assessment of GFR also requires a 24 h urine collection which is not convenient and may be subject to additional preanalytical errors. WHAT IS THE NEW OLD? Morgan G, Goolam-Mahomed Z, Hodson J, Nath J, Sharif A. Donor-recipient sex differences do not affect survival outcomes after kidney transplantation: a population cohort study. The outcomes have improved dramatically with the development of matching rules. Comparative analysis of ABO-incompatible living donor kidney transplantation with ABO-compatible grafts: a single-center experience in Korea. When there are HLA mismatches, requirement for higher immunosuppression doses and more antirejection therapy are needed, thus it is associated with short-term adverse function because of infection or cardiovascular disease during the first year after kidney transplantation, which persisted but was far less marked during years 2–5 (35). (2013) 27:764–71. Non-Han patients have a faster CysC recovery than Han patients 3 months−2 years after surgery (P < 0.05). Zhonghua Yi Xue Za Zhi. Nevertheless, one limitation of our study is that the various minorities were not studied separately to determine which minority may have the best graft condition because the sample size available for separate analysis of each national minority was small. Methods: In this retrospective analysis, a total of 2,462 recipients receiving allogeneic kidney transplantation in West China Hospital of Sichuan University from December 13, 2008 to January 10, 2018 were included. In total, Frontiers articles have received more than 700,000 citations to date. Moreover, in our research, most patients received kidney transplantation from their relatives. Creatinine-based equations for estimation of GFR (eGFR) were established to overcome some of these inadequacies (40). A contemporary analysis of outcomes and modifiable risk factors of ethnic disparities in kidney transplantation. After 23 years at the University of Pennsylvania as the C. Mahlon Kline Professor of Medicine, chief of the Renal-Electrolyte and Hypertension Division, and director of the Penn Center for Molecular Studies of Kidney Diseases, he … The relationship between donors and recipients was predominantly relative (79.8%), while unrelated donors, including spouse donors, a foster father and DCD, comprised 20.2% (Table 1). Additionally, the frequency of blood group O significantly increased in the donor population compared with the recipients in our study. Transplantation. doi: 10.1111/j.1432-2277.2002.tb00091.x, 31. Thereafter, even when anti-A/B antibodies recur at high levels they will not harm the kidney transplant, a phenomenon that is called accommodation (13). 9:30AM to 6:30PM JST Shonan iPark, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, JPN. Then the subsequent data organization and analysis of included population are demonstrated. Hence ophthalmologists as doctors not only have much to offer to advance our own discipline but also to advance medicine as a whole. Frontiers Editorial Office Avenue du Tribunal Fédéral 34 CH – 1005 Lausanne Switzerland Tel +41(0)21 510 17 40 Fax +41 (0)21 510 17 01, medicine.editorial.office@frontiersin.org, Frontiers Support Tel +41(0)21 510 17 10 Fax +41 (0)21 510 17 01 support@frontiersin.org, Avenue du Tribunal Fédéral 34 CH – 1005 Lausanne Switzerland, Tel +41(0)21 510 17 40 Fax +41 (0)21 510 17 01, For all queries regarding manuscripts in Review and potential conflicts of interest, please contact The Nephrology section provides a forum for innovative communication and cross-fertilization of rigorous basic, translational, and clinical research from physician/scientists/practitioners and trainees who aim to publish their strongest work in this section. doi: 10.1111/ajt.14631, 10. The studies involving human participants were reviewed and approved by the Biomedical Ethics Subcommittee of West China Hospital of Sichuan University [reference No. Written informed consent from the participants' legal guardian/next of kin was not required to participate in this study in accordance with the national legislation and the institutional requirements. Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. In our study, kidneys were mainly from living donors which may be beneficial to better outcomes of recipients. (2006) 145:247–54. Transpl Int. First, analyzing factors univariately without combination may ignore the interaction and confounding impact on outcomes (11). This is consistent with earlier studies (20, 33) and has great clinical value. This section provides an Open Access publication forum with rapid turnaround, for high quality research in pulmonary diseases, utilizing an online strategy and efficient review process. An emphasis is placed on diagnostic technology, investigations relevant … Heart Fail Rev. Dunn TB, Noreen H, Gillingham K, Maurer D, Ozturk OG, Pruett TL, et al. (2017) 8:234. doi: 10.3389/fimmu.2017.00234, 14. Hu XP, Tian Y, Zhu TY, Chen JH, Wang CX, Li XT, et al. Stegall MD, Dean PG, Gloor JM. Frontiers journals lead in citations & rank in the top Impact Factor and CiteScore percentiles. Hwang JK, Kim YK, Kim JM, Chung BH, Choi BS, Yang CW, et al. Opposite effects of testosterone and estrogens on chronic allograft nephropathy. The results showed that the recipient gender, ethnicity, BMI, and donor age were independent factors affecting postoperative CysC recovery thus reflecting kidney function in renal transplant recipients (P < 0.05). Impact Factor 3.9 | CiteScore 4.3 More on impact › ... New advances in medicine and affiliated fields greatly impact the work of clinicians and call for interdisciplinary collaborations, emphasizing the need to remodel preparation programs for graduates in academic nephrology and clinical practice. medicine.editorial.office@frontiersin.org, For queries regarding Research Topics, Editorial Board applications, and journal development, please contact Univariate and multivariate logistic regression analyses were carried out on the study variables, and kidney function of postoperative patients was monitored using cystatin C (CysC) as the outcome indicator. (2018) 18:1914–23. 3.518. Hu XJ, Zheng J, Li Y, Tian XH, Tian PX, Xiang HL, et al. Different from previous research, this study used a laboratory indicator CysC, which was not subject to gender, age, or weight (39), to predict renal transplantation kidney function outcomes. In addition to the 2-year Journal Impact, the 3-year Journal Impact can provide further insights and factors into the impact of Frontiers in Neuroscience. North America . ABO-incompatible kidney transplantation. The datasets analyzed in this article are anonymous to protect patient privacy and are not publicly available. Authors. However, estimation equations are reliable only in stable conditions and should not be used when rapid changes of renal function occur (41). While in China there have been few studies analyzing factors of recipients and donors influencing kidney function after transplantation, and no comparisons among diverse ethnic groups (17–21). J Clin Invest. The temporal and long-term impact of donor body mass index on recipient outcomes after kidney transplantation - a retrospective study. Friday, April 26, 2019. This was linked to our kidney allocation principle. Figure 1 displays the derivation of our research process including the inclusion and exclusion of subjects and the organization and analyses of data. Consequently, it led to a higher proportion of O blood type among donors. Therefore, it's high time to conduct corresponding research to provide references for kidney transplantation in China. A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010. Journal Impact Prediction System provides an open, transparent, and straightforward platform to help academic researchers Predict future Metric and performance through the wisdom of crowds. Younger recipients may have stronger immune systems and higher functioning nephrons, leading to faster recovery. Transplant Proc. Nephrol Dial Transplant. Impact Factor Database Search Engine. Additionally, the sample size of each research study has been limited, ranging from 300 to 600 participants (18, 20, 22). Prognostic significance of serum cystatin c concentrations in renal transplant recipients: 5-year follow-up. However, this marker has several well-known limitations such as dependent on a number of factors including tubular resorption, total muscle mass, nutritional status, age and gender. doi: 10.1111/j.1399-0012.2010.01241.x, 5. doi: 10.1016/j.transproceed.2012.08.014, 18. (2020) 33:59–67. Scope. ZX, LW, and XL engaged in the acquisition of data (laboratory or clinical). This is understandable because BMI has a significant impact on gender-dependent responses to renal transplantation. (2012) 12:3031–8. The Official Publication of the Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine. Risk factors for acute rejection in living-donor kidney transplant recipients in China: a subgroup analysis of a multi-center, registry study. Moreover, we incorporated time-hierarchical analysis to discover which postoperative time point was most critical. Frontiers of Medicine is a peer-reviewed online-only general medical journal published jointly by the Chinese Higher Education Press and Springer Science+Business Media. Chen GD, Shiu-Chung Ko D, Wang CX, Qiu J, Han M, He XS, et al. (2015) 30:1972–8. doi: 10.1097/01.TP.0000136263.46262.0D, 38. Frontiers in Chemistry. Donor and recipient characteristics were enrolled and matched in the Transplant Center Database before transplantation. The birth of a new medical journal is always exciting and at the same time a great challenge. doi: 10.1111/j.1600-6143.2011.03640.x, 25. (2009) 87:1246–55. doi: 10.1111/ajt.14694, 26. South America . (2019) 111:202–9. Opelz G, Döhler B. Based on the multivariate logistic regression analyses, we found that gender, ethnicity, BMI of recipients, and age of donors were independent influence factors. Transplant Proc. Improving utilization of deceased donor kidneys by matching recipient and graft survival. Africa . 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